Liquisolid Compacts: An Approach to Enhance the. Dissolution Rate of Nimesulide. Srinivas Vaskula, Sateesh Kumar Vemula, Vijaya Kumar. PDF | ABSTACT Liquisolid compacts were used to formulate water insoluble drugs in non volatile solvents and convert into acceptable flowing. PDF | The aim of this study was to investigate the use of liquisolid technique in improving the dissolution of Glimepiride in a solid dosage form. This study was.

Author: Zolomi Gozragore
Country: Kenya
Language: English (Spanish)
Genre: Literature
Published (Last): 23 July 2007
Pages: 129
PDF File Size: 5.1 Mb
ePub File Size: 14.54 Mb
ISBN: 803-7-56525-476-3
Downloads: 27988
Price: Free* [*Free Regsitration Required]
Uploader: Kigalmaran

Cumulative percent drug release was plotted as a function of time, and percent drug release in 5 minutes was calculated. It can be concluded from this study that novel porous carriers are superior to traditional carriers in liquisolid systems and are suitable for loading high dose liqhisolid like CBZ. Fujicalin, also to some extent, proved to be a better carrier than Avicel.

Authors and affiliation s: Due to significantly increased wetting properties and surface area of the drug particles available for dissolution, liquisolid tablets were expected to enhance drug release characteristics and, consequently, improved oral bioavailability.

Formulation and Evaluation of Liquisolid Compacts for Olmesartan Medoxomil

This is an open access article distributed under the Creative Commons Attribution Licensewhich permits unrestricted liquidolid, distribution, and reproduction in any medium, provided the original work is properly cited. Moreover, the inclusion of disintegrating agents may further enhance the drug release from this system. A powder may be able to retain only limited liqulsolid of liquid while maintaining acceptable flow and compression properties. The objective of the present investigation was to develop liquisolid compacts for olmesartan medoxomil to improve the dissolution rate.

Figures 3 a and 3 b show the thermogram for olmesartan medoxomil and liquisolid mixture. Journal of Drug Delivery. Permissions beyond the scope of this license may be available with editor ijper.

Olmesartan medoxomil is an angiotensin type II receptor blocker, antihypertensive agent, administered orally. The several mechanisms by which solubility enhancement takes place have been postulated for liquisolid systems.

Liquisolid Compact Technique: A Novel Approach to Solubility Enhancement | OMICS International

The three principal suggested mechanisms include an increased surface area of drug particles, an increased aqueous solubility, and an improved wettability of the drug particles. Solubility and dissolution are the core concepts of any physical or chemical science including biopharmaceutical and pharmacokinetic considerations in therapy of any medicine.


The liquisolid approach is a potential technology due to its simplified manufacturing method, cheaper production costs and the prospect of industrial scale up due to the good flow and compaction properties.

The prepared liquisolid compacts were evaluated and compared for thickness, diameter, weight variation, uniformity of content, hardness, friability, disintegration and in vitro dissolution. Among the newly developed drugs which are meant for oral administration, around half exhibit solubility problem in water, which affects the formulation development process.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

This could be probably due to the presence of higher amounts of silica in and lower in. Solubility data of drug olmesartan medoxomil in various liquid vehicles is shown in Table 2.

This would explain the improved drug dissolution from liquisolid compared to conventional preparations. Composition of liquids solid compacts batches is shown in Table 1. Fujicalin Dibasic calcium phosphate anhydrous and Neusilin Magnesium aluminometasilicate were obtained as gift sample from Fuji Chemical Industry Co.

Olmesartan medoxomil is a novel selective angiotensin II receptor blocker that is approved for treatment of hypertension [ 6 ]. At higher values the greater amount of carrier may overcome to some extent the flow properties of powder. Journal of Pharmaceutical Scienceand Research 3: From the results of different batches prepared by three different carriers shown oiquisolid Table 6 cmopacts, it was found that Neusilin proved to be the superior carrier than others.

Guidelines Upcoming Special Issues. The tensile strength of the tablet was also sufficient. International Journal of ChemTech Research 2: Oiquisolid in Web of Science.

The authors certify that there is no conflict of interests with compavts financial organization regarding the material discussed in the paper. Amongst carriers used Fujicalin and Neusilin were found to be more effective carrier materials for liquid adsorption. Results of hardness, friability, and disintegration time are represented in Table 4. Most of hydrophobic drugs show very poor dissolution in the gastro intestinal tract, leading to erratic and incomplete drug absorption.

The flowability improvement can be attributed to the high porosity and high specific surface area of these excipients, which allows penetration of liquid into the particle pores resulting in a weight gain of individual particle accompanied by better flow properties.


Liquisolid Compact Technique: A Novel Approach to Solubility Enhancement

Pharmaceutical Sciences Journals Ann Jose ankara escort. The poor dissolution rate of water-insoluble drugs is still a major problem confronting the pharmaceutical industry. Concentration of dissolved drug was determined using standard equation. Related article at PubmedScholar Google. Six tablets from each formulation were tested for hardness. These peaks can be considered as characteristic peaks of olmesartan medoxomil and were not affected and prominently observed in IR spectra of olmesartan medoxomil along with oil and carrier materials shown in Figure 4 b.

IR spectrum of pure Olmesartan medoxomil shown in Figure 4 aan absorption band was observed, peaks It is highly lipophilic log P 5.

Hence, the objective of the present work was to formulate the liquisolid compacts for olmesartan medoxomil to improve the solubility and dissolution rate, which can increase clinical efficacy or reduce the oral dosage required to achieve the same effect.

Powder flowability is crucial in the industrial production of tablet dosage forms, as a uniform powder stream through hopper confirms uniformity of both tablet weight and drug content.

The lowest liquid factor was obtained for Avicel PHand accordingly, the amount of carrier was higher than other formulations. The less drug concentration in the vehicle means more fraction of the drug is liable to be in the liquid solution form i. All liquisolid preparations were compacted into tablets using a ten-station rotary compression machine Rimek, Karnavati Engineering, India using flat-faced punch with a compression force that provide acceptable tablet hardness.

The hardness of the tablets was determined using Monsanto hardness tester.

The solubility of several therapeutic agents is an important technical challenge in formulating as a suitable dosage form efficient its drug delivery [ 12 ]. The highest liquid factor was obtained for Neusilin, and accordingly, compacgs amount of carrier was lower than other formulations. In the formulation development process solubility of active compound is one of the main criteria considered before deciding the dosage form.

Related Posts